Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model.

Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model.

Insulin-like growth factor I (IGF-I) and its type I receptor (IGF-IR) play significant roles in tumorigenesis and in immune response. Here, we wanted to know whether an RNA interference approach targeted to IGF-IR could be used for specific antitumor immunostimulation in a breast cancer model. For t...

Full description

Bibliographic Details
Main Authors: Tiphanie Durfort, Mercedes Tkach, Mariya I Meschaninova, Martín A Rivas, Patricia V Elizalde, Alya G Venyaminova, Roxana Schillaci, Jean-Christophe François
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22235273/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22235273/?tool=EBI

Similar Items