Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

Earlier evidences showed that diglycosyl diselenides are active against the infective stage of African trypanosomes (top hits IC50 0.5 and 1.5 μM) but poorly selective (selectivity index <10). Here we extended the study to 33 new seleno-glycoconjugates with the aim to improve potency and selectiv...

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Bibliographic Details
Main Authors: Estefanía Dibello, Natalia Oddone, Jaime Franco, Tünde-Zita Illyés, Andrea Medeiros, Attila Kiss, Fanni Hőgye, Katalin E. Kövér, László Szilágyi, Marcelo A. Comini
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Selenoglycosides
Bloodstream trypanosoma
Macrophage
Redox biosensor
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320724000101

Internet

http://www.sciencedirect.com/science/article/pii/S2211320724000101

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