Effect of weight loss on knee joint synovitis over 48 months and mediation by subcutaneous fat around the knee: data from the Osteoarthritis Initiative

Effect of weight loss on knee joint synovitis over 48 months and mediation by subcutaneous fat around the knee: data from the Osteoarthritis Initiative

Abstract Background Obesity influences the development of osteoarthritis via low-grade inflammation. Progression of local inflammation (= synovitis) increased with weight gain in overweight and obese women compared to stable weight. Synovitis could be associated with subcutaneous fat (SCF) around th...

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Bibliographic Details
Main Authors: Maximilian T. Löffler, Chotigar Ngarmsrikam, Paula Giesler, Gabby B. Joseph, Zehra Akkaya, John A. Lynch, Nancy E. Lane, Michael Nevitt, Charles E. McCulloch, Thomas M. Link
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Musculoskeletal Disorders
Subjects:
Osteoarthritis
Weight loss
Synovitis
Mediation analysis
Effusion
Hoffa’s fat pad
Online Access:https://doi.org/10.1186/s12891-024-07397-y

Internet

https://doi.org/10.1186/s12891-024-07397-y

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