An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity

An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity

Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence. Introduction of the telomerase (hTERT) cDNA is sufficient to produce telomerase ac...

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Bibliographic Details
Main Authors: Xiaoming Yi, Dennis M. White, Dara L. Aisner, Joseph A. Baur, Woodring E. Wright, Jerry W. Shay
Format: Article
Language:English
Published: Elsevier 2000-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
human telomerase
alternate splicing
dominant-negative inhibitor
telomere
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558600800135

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http://www.sciencedirect.com/science/article/pii/S1476558600800135

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