Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway

Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway

The presence of gastric cancer stem cells (GCSCs) marks the onset of gastric carcinoma. The sonic hedgehog (SHH) pathway plays a vital role in the maintenance of GCSC characteristics. Apatinib has been approved in China for advanced gastric cancer (GC) treatment. However, whether apatinib can target...

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Bibliographic Details
Main Authors: Wanshuang Cao, Yuan Li, Hongliang Sun, Chenying Yang, Jianyun Zhu, Chunfeng Xie, Xiaoting Li, Jieshu Wu, Shanshan Geng, Lu Wang, Liangfei Sun, Guozhu Geng, Hongyu Han, Caiyun Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
apatinib
gastric cancer stem cells
sonic hedgehog pathway
suppression
chemoresistance
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.679806/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.679806/full

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