Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway

Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway

Elevated plasma non-esterified fatty acid (NEFA) levels and hepatocytes damage are characteristics of ketosis in dairy cows. Oxidative stress is associated with the pathogenesis of NEFA-induced liver damage. However, the exact mechanism by which oxidative stress mediates NEFA-induced hepatocytes apo...

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Bibliographic Details
Main Authors: Yu Li, Hongyan Ding, Leihong Liu, Yuxiang Song, Xiliang Du, Shibin Feng, Xichun Wang, Xiaobing Li, Zhe Wang, Xinwei Li, Jinchun Li, Jinjie Wu, Guowen Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
NEFA
apoptosis
mitochondria-mediated ROS-JNK/ERK signaling pathway
dairy cow
hepatocyte
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00245/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00245/full

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