Tolvaptan versus fluid restriction in acutely hospitalised patients with moderate-profound hyponatraemia (TVFR-HypoNa): design and implementation of an open-label randomised trial

Tolvaptan versus fluid restriction in acutely hospitalised patients with moderate-profound hyponatraemia (TVFR-HypoNa): design and implementation of an open-label randomised trial

Abstract Background Current hyponatraemia guidelines are divided on the use of tolvaptan in hospitalised patients with moderate to severe hyponatraemia, due to an uncertain risk-benefit ratio. We will conduct a randomised trial to test the hypothesis that early use of tolvaptan improves the rate of...

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Bibliographic Details
Main Authors: Annabelle M. Warren, Mathis Grossmann, Rudolf Hoermann, Jeffrey D. Zajac, Nicholas Russell
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Trials
Subjects:
Hyponatraemia
Tolvaptan
Fluid restriction
Syndrome of inappropriate antidiuresis (SIAD)
Online Access:https://doi.org/10.1186/s13063-022-06237-5

Internet

https://doi.org/10.1186/s13063-022-06237-5

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