The non-random clustering of non-synonymous substitutions and its relationship to evolutionary rate
<p>Abstract</p> <p>Background</p> <p>Protein sequences are subject to a mosaic of constraint. Changes to functional domains and buried residues, for example, are more apt to disrupt protein structure and function than are changes to residues participating in loops or ex...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-08-01
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| Series: | BMC Genomics |
| Online Access: | http://www.biomedcentral.com/1471-2164/12/415 |