Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload

Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload

Summary: Activated factor X is a key component of the coagulation cascade, but whether it directly regulates pathological cardiac remodeling is unclear. In mice subjected to pressure overload stress, cardiac factor X mRNA expression and activity increased concurrently with cardiac hypertrophy, fibro...

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Main Authors: Xinji Guo, PhD, Mikhail A. Kolpakov, MD, PhD, Bahman Hooshdaran, PhD, William Schappell, BS, Tao Wang, MD, PhD, Satoru Eguchi, MD, PhD, Katherine J. Elliott, PhD, Douglas G. Tilley, PhD, A. Koneti Rao, MD, Patricia Andrade-Gordon, PhD, Matthew Bunce, PhD, Chintala Madhu, PhD, Steven R. Houser, PhD, Abdelkarim Sabri, PhD
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19303146

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http://www.sciencedirect.com/science/article/pii/S2452302X19303146

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