Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB.

Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB.

Celastrol is a natural proteasome inhibitor that exhibits promising anti-tumor effects in human malignancies, especially the androgen-independent prostate cancer (AIPC) with constitutive NF-κB activation. Celastrol induces apoptosis by means of proteasome inhibition and suppresses prostate tumor gro...

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Bibliographic Details
Main Authors: Yao Dai, Jeffrey Desano, Wenhua Tang, Xiaojie Meng, Yang Meng, Ezra Burstein, Theodore S Lawrence, Liang Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3000808?pdf=render

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http://europepmc.org/articles/PMC3000808?pdf=render

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