Profiling protease cleavage patterns in plasma for pancreatic cancer detection

Abstract Proteases are promising biomarkers for cancer early detection. Their enzymatic activity against peptide substrates allows for their straightforward detection using low-cost tests. However, the complexity of the human proteome makes it challenging to develop sensitive and selective tests aga...

Full description

Bibliographic Details
Main Authors: Morgan R. Stewart, Arnaud Quentel, Elise Manalo, Jose Montoya Mira, Srivathsan Ranganathan, Bruce P. Branchaud, Jared M. Fischer, Eugene Tu, Fehmi Civitci, Yu-Jui Chiu, Adem Yildirim
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-83077-0