Alkaline sphingomyelinase (NPP7) impacts the homeostasis of intestinal T lymphocyte populations

Alkaline sphingomyelinase (NPP7) impacts the homeostasis of intestinal T lymphocyte populations

Background and aimAlkaline sphingomyelinase (NPP7) is expressed by intestinal epithelial cells and is crucial for the digestion of dietary sphingomyelin. NPP7 also inactivates proinflammatory mediators including platelet-activating factor and lysophosphatidylcholine. The aim of this study was to exa...

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Bibliographic Details
Main Authors: Manar Alyamani, Mohammad Kadivar, Jonas Erjefält, Bengt Johansson-Lindbom, Rui-Dong Duan, Åke Nilsson, Jan Marsal
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
alkaline sphingomyelinase
NPP7
inflammatory bowel disease
intestine
knockout
S1P
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050625/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050625/full

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