PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to Primary Cilia

PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to Primary Cilia

Mutations in PDE6D impair the function of its cognate protein, phosphodiesterase 6D (PDE6D), in prenylated protein trafficking towards the ciliary membrane, causing the human ciliopathy Joubert Syndrome (JBTS22) and retinal degeneration in mice. In this study, we purified the prenylated cargo of PDE...

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Bibliographic Details
Main Authors: Siebren Faber, Stef J. F. Letteboer, Katrin Junger, Rossano Butcher, Trinadh V. Satish Tammana, Sylvia E. C. van Beersum, Marius Ueffing, Rob W. J. Collin, Qin Liu, Karsten Boldt, Ronald Roepman
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
PDE6D
FAM219A
NIM1K
UBL3
protein trafficking
prenylation
Online Access:https://www.mdpi.com/2073-4409/12/2/312

Internet

https://www.mdpi.com/2073-4409/12/2/312

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