The Covert Surge: Murine Bile Acid Levels Are Associated With Pruritus in Pediatric Autoimmune Sclerosing Cholangitis

The Covert Surge: Murine Bile Acid Levels Are Associated With Pruritus in Pediatric Autoimmune Sclerosing Cholangitis

ObjectivesThe exact etiology of pruritus in chronic cholestasis is unknown. Pruritus intensity does not correlate with common biochemical indices and there is a lack of biomarkers guiding diagnosis and treatment. We explored profiles of bile acids (BA) and muricholic acids (MCA) as well as autotaxin...

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Bibliographic Details
Main Authors: Katharina Meinel, Doloresz Szabo, Antal Dezsofi, Sina Pohl, Tanja Strini, Theresa Greimel, Victor Aguiriano-Moser, Harald Haidl, Martin Wagner, Axel Schlagenhauf, Jörg Jahnel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pediatrics
Subjects:
muricholic acid
autotaxin (ATX)
bile acid (BA)
autoimmune sclerosing cholangitis
pediatrics
pruritus
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.903360/full

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https://www.frontiersin.org/articles/10.3389/fped.2022.903360/full

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