Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli

Kidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify internalized bacteria, similarly to professional phagoc...

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Bibliographic Details
Main Authors: Vijay Saxena, Hongyu Gao, Samuel Arregui, Amy Zollman, Malgorzata Maria Kamocka, Xiaoling Xuei, Patrick McGuire, Michael Hutchens, Takashi Hato, David S. Hains, Andrew L. Schwaderer
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22672-5