Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli
Kidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify internalized bacteria, similarly to professional phagoc...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22672-5 |
| _version_ | 1818751989680439296 |
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| author | Vijay Saxena Hongyu Gao Samuel Arregui Amy Zollman Malgorzata Maria Kamocka Xiaoling Xuei Patrick McGuire Michael Hutchens Takashi Hato David S. Hains Andrew L. Schwaderer |
| author_facet | Vijay Saxena Hongyu Gao Samuel Arregui Amy Zollman Malgorzata Maria Kamocka Xiaoling Xuei Patrick McGuire Michael Hutchens Takashi Hato David S. Hains Andrew L. Schwaderer |
| author_sort | Vijay Saxena |
| collection | DOAJ |
| description | Kidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify internalized bacteria, similarly to professional phagocytes. |
| first_indexed | 2024-12-18T04:44:20Z |
| format | Article |
| id | doaj.art-12b0361daf0f4717825e3b4c2f6ce834 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:44:20Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-12b0361daf0f4717825e3b4c2f6ce8342022-12-21T21:20:37ZengNature PortfolioNature Communications2041-17232021-04-0112111510.1038/s41467-021-22672-5Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coliVijay Saxena0Hongyu Gao1Samuel Arregui2Amy Zollman3Malgorzata Maria Kamocka4Xiaoling Xuei5Patrick McGuire6Michael Hutchens7Takashi Hato8David S. Hains9Andrew L. Schwaderer10Indiana University School of Medicine, Department of Pediatrics, Division of NephrologyIndiana University School of Medicine, Department of Medical & Molecular GeneticsIndiana University School of Medicine, Department of Pediatrics, Division of NephrologyIndiana University School of Medicine, Department of Medicine, Division of NephrologyIndiana University School of Medicine, Department of Medicine, Division of NephrologyIndiana University School of Medicine, Department of Medical & Molecular GeneticsIndiana University School of Medicine, Department of Medical & Molecular GeneticsOregon Health and Science University, Department of Anesthesiology & Perioperative MedicineIndiana University School of Medicine, Department of Medicine, Division of NephrologyIndiana University School of Medicine, Department of Pediatrics, Division of NephrologyIndiana University School of Medicine, Department of Pediatrics, Division of NephrologyKidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify internalized bacteria, similarly to professional phagocytes.https://doi.org/10.1038/s41467-021-22672-5 |
| spellingShingle | Vijay Saxena Hongyu Gao Samuel Arregui Amy Zollman Malgorzata Maria Kamocka Xiaoling Xuei Patrick McGuire Michael Hutchens Takashi Hato David S. Hains Andrew L. Schwaderer Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli Nature Communications |
| title | Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli |
| title_full | Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli |
| title_fullStr | Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli |
| title_full_unstemmed | Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli |
| title_short | Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli |
| title_sort | kidney intercalated cells are phagocytic and acidify internalized uropathogenic escherichia coli |
| url | https://doi.org/10.1038/s41467-021-22672-5 |
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