Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains

Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains

Previous reports have shown that individual neurons of the brain can display somatic genomic mosaicism of unknown function. In this study, we report altered genomic mosaicism in single, sporadic Alzheimer's disease (AD) neurons characterized by increases in DNA content and amyloid precursor pro...

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Bibliographic Details
Main Authors: Diane M Bushman, Gwendolyn E Kaeser, Benjamin Siddoway, Jurgen W Westra, Richard R Rivera, Stevens K Rehen, Yun C Yung, Jerold Chun
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-02-01
Series:eLife
Subjects:
somatic mosaicism
CNV
amyloid precursor protein
AD
Online Access:https://elifesciences.org/articles/05116

Internet

https://elifesciences.org/articles/05116

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