Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

Abstract The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation, histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide biosynthesis. The SGOC pathway is a crucial metabolic network in tumorigenesis, wherein the outputs are required...

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Bibliographic Details
Main Authors: Wei Sun, Ruochen Liu, Xinyue Gao, Zini Lin, Hongao Tang, Hongjuan Cui, Erhu Zhao
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Biomarker Research
Subjects:
Serine-glycine-one-carbon metabolism
Vulnerability
Metabolic enzyme inhibitors
Immunotherapy
Ferroptosis
Online Access:https://doi.org/10.1186/s40364-023-00487-4

Internet

https://doi.org/10.1186/s40364-023-00487-4

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