Anti-inflammatory role of GM1 and other gangliosides on microglia

Anti-inflammatory role of GM1 and other gangliosides on microglia

Abstract Background Gangliosides are glycosphingolipids highly enriched in the brain, with important roles in cell signaling, cell-to-cell communication, and immunomodulation. Genetic defects in the ganglioside biosynthetic pathway result in severe neurodegenerative diseases, while a partial decreas...

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Bibliographic Details
Main Authors: Danny Galleguillos, Qian Wang, Noam Steinberg, Asifa Zaidi, Gaurav Shrivastava, Kamaldeep Dhami, Gour C. Daskhan, Edward N. Schmidt, Zoë Dworsky-Fried, Fabrizio Giuliani, Matthew Churchward, Christopher Power, Kathryn Todd, Anna Taylor, Matthew S. Macauley, Simonetta Sipione
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Neuroinflammation
Subjects:
Gangliosides
GM1
GENZ-123346
L–t-PDMP
Liposomes
Microglia
Online Access:https://doi.org/10.1186/s12974-021-02374-x

Internet

https://doi.org/10.1186/s12974-021-02374-x

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