Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1

Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1

Abstract Background A range of neurological pathologies may lead to secondary hydrocephalus. Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as specific and efficient pharmacological options are lacking, partly due to the elusive molecular nature of the CSF secret...

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Bibliographic Details
Main Authors: Trine L. Toft-Bertelsen, Dagne Barbuskaite, Eva Kjer Heerfordt, Sara Diana Lolansen, Søren Norge Andreassen, Nina Rostgaard, Markus Harboe Olsen, Nicolas H. Norager, Tenna Capion, Martin Fredensborg Rath, Marianne Juhler, Nanna MacAulay
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Fluids and Barriers of the CNS
Subjects:
Transient receptor potential vanilloid 4
Choroid plexus
LPA
Membrane transport
Intraventricular hemorrhage
IVH
Online Access:https://doi.org/10.1186/s12987-022-00361-9

Internet

https://doi.org/10.1186/s12987-022-00361-9

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