Genome Mining and Metabolic Profiling Reveal Cytotoxic Cyclodipeptides in <i>Streptomyces hygrospinosus</i> var. Beijingensis

Genome Mining and Metabolic Profiling Reveal Cytotoxic Cyclodipeptides in <i>Streptomyces hygrospinosus</i> var. Beijingensis

Two new cyclodipeptide (CDP) derivatives (<b>1–2</b>) and another seven known cyclodipeptides (<b>3–9</b>) were isolated from <i>Streptomyces</i> 26D9-414 by the genome mining approach combined with genetic dereplication and the “one strain many compounds” (OSMAC)...

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Bibliographic Details
Main Authors: Dashan Zhang, Junbo Wang, Yongjian Qiao, Baixin Lin, Zixin Deng, Lingxin Kong, Delin You
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antibiotics
Subjects:
genome mining
genetic dereplication
cyclodipeptide
OSMAC
cytotoxicity
<i>Streptomyces</i>
Online Access:https://www.mdpi.com/2079-6382/11/11/1463

Internet

https://www.mdpi.com/2079-6382/11/11/1463

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