Randomized, placebo controlled phase I trial of the safety, pharmacokinetics, pharmacodynamics and acceptability of a 90 day tenofovir plus levonorgestrel vaginal ring used continuously or cyclically in women: The CONRAD 138 study.

Randomized, placebo controlled phase I trial of the safety, pharmacokinetics, pharmacodynamics and acceptability of a 90 day tenofovir plus levonorgestrel vaginal ring used continuously or cyclically in women: The CONRAD 138 study.

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Multipurpose prevention technologies (MPTs), which prevent sexually transmitted infection(s) and unintended pregnancy, are highly desirable to women. In this randomized, placebo-controlled, phase I study, women used a placebo or tenofovir (TFV) and levonorgestrel (LNG) intravaginal ring (IVR), eithe...

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Bibliographic Details
Main Authors: Andrea R Thurman, Vivian Brache, Leila Cochon, Louise A Ouattara, Neelima Chandra, Terry Jacot, Nazita Yousefieh, Meredith R Clark, Melissa Peet, Homaira Hanif, Jill L Schwartz, Susan Ju, Mark A Marzinke, David W Erikson, Urvi Parikh, Betsy C Herold, Raina N Fichorova, Elizabeth Tolley, Gustavo F Doncel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0275794

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https://doi.org/10.1371/journal.pone.0275794

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