Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca<sup>2+</sup>]<sub>i,</sub><it>I</it><sub>Ca</sub>, and Ca<sup>2+</sup> transients in HL-1 cardiomyocytes

Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca<sup>2+</sup>]<sub>i,</sub><it>I</it><sub>Ca</sub>, and Ca<sup>2+</sup> transients in HL-1 cardiomyocytes

<p>Abstract</p> <p>The phosphoinositide 3-kinases (PI3K/Akt) dependent signaling pathway plays an important role in cardiac function, specifically cardiac contractility. We have reported that sepsis decreases myocardial Akt activation, which correlates with cardiac dysfunction in s...

Full description

Bibliographic Details
Main Authors: Graves Bridget M, Simerly Thomas, Li Chuanfu, Williams David L, Wondergem Robert
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Journal of Biomedical Science
Subjects:
Calcium
Fura-2
Phosphoinositide-3-kinase/Akt
HL-1 cardiomyocytes
Whole-cell voltage clamp
Electrophysiology
Online Access:http://www.jbiomedsci.com/content/19/1/59

Internet

http://www.jbiomedsci.com/content/19/1/59

Similar Items