Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p
By identifying circ-CREBBP out of differently expressed circRNAs in seminal plasma extracellular vesicles from boars with high and low sperm motility, the circRNA is shown to play a role in sperm survival and apoptosis.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04263-2 |
| _version_ | 1811188915762102272 |
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| author | Ning Ding Yu Zhang Mengna Huang Jianfeng Liu Chonglong Wang Chun Zhang Jinkang Cao Qin Zhang Li Jiang |
| author_facet | Ning Ding Yu Zhang Mengna Huang Jianfeng Liu Chonglong Wang Chun Zhang Jinkang Cao Qin Zhang Li Jiang |
| author_sort | Ning Ding |
| collection | DOAJ |
| description | By identifying circ-CREBBP out of differently expressed circRNAs in seminal plasma extracellular vesicles from boars with high and low sperm motility, the circRNA is shown to play a role in sperm survival and apoptosis. |
| first_indexed | 2024-04-11T14:27:27Z |
| format | Article |
| id | doaj.art-12bf96ae0bab445490552d275c2a9fba |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T14:27:27Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-12bf96ae0bab445490552d275c2a9fba2022-12-22T04:18:48ZengNature PortfolioCommunications Biology2399-36422022-12-015111710.1038/s42003-022-04263-2Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3pNing Ding0Yu Zhang1Mengna Huang2Jianfeng Liu3Chonglong Wang4Chun Zhang5Jinkang Cao6Qin Zhang7Li Jiang8National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural UniversityKey Laboratory of Pig Molecular Quantitative Genetics of Anhui Academy of Agricultural Sciences, Anhui Provincial Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural SciencesNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding & Reproduction, Ministry of Agriculture, College of Animal Science & Technology, China Agricultural UniversityBy identifying circ-CREBBP out of differently expressed circRNAs in seminal plasma extracellular vesicles from boars with high and low sperm motility, the circRNA is shown to play a role in sperm survival and apoptosis.https://doi.org/10.1038/s42003-022-04263-2 |
| spellingShingle | Ning Ding Yu Zhang Mengna Huang Jianfeng Liu Chonglong Wang Chun Zhang Jinkang Cao Qin Zhang Li Jiang Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p Communications Biology |
| title | Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p |
| title_full | Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p |
| title_fullStr | Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p |
| title_full_unstemmed | Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p |
| title_short | Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p |
| title_sort | circ crebbp inhibits sperm apoptosis via the pi3k akt signaling pathway by sponging mir 10384 and mir 143 3p |
| url | https://doi.org/10.1038/s42003-022-04263-2 |
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