Detection of innate immune response modulating impurities (IIRMI) in therapeutic peptides and proteins: Impact of excipients

Detection of innate immune response modulating impurities (IIRMI) in therapeutic peptides and proteins: Impact of excipients

Unintended immunogenicity can affect the safety and efficacy of therapeutic proteins and peptides, so accurate assessments of immunogenicity risk can aid in the selection, development, and regulation of biologics. Product- and process- related impurities can act as adjuvants that activate the local...

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Bibliographic Details
Main Authors: Seth G. Thacker, Cheng Her, Logan Kelley-Baker, Derek D C. Ireland, Mohanraj Manangeeswaran, Eric S. Pang, Daniela Verthelyi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
immunogenicity
excipient
IIRMI
In vitro model
reporter cell lines
masking
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.970499/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.970499/full

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