Transient temperature fluctuations severely decrease P. falciparum susceptibility to artemisinin in vitro

Clinical studies suggest that outcomes for hospitalised malaria patients can be improved by managed hypothermia during treatment. We examined the impact of short pulses of low temperature on ring-stage susceptibility of Plasmodium falciparum to artemisinin in vitro. The usually artemisinin-sensitive...

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Bibliographic Details
Main Authors: Ryan C. Henrici, Donelly A. van Schalkwyk, Colin J. Sutherland
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320718301167