Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera

Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera

Here, Rathnasinghe et al. characterize the pathogenesis of a mouse-adapted SARS-CoV-2 in infected obese and aged mice, and identify mutations that are present in SARS-CoV-2 variants of concern, associated with higher transmissibility.

Bibliographic Details
Main Authors:	Raveen Rathnasinghe, Sonia Jangra, Chengjin Ye, Anastasija Cupic, Gagandeep Singh, Carles Martínez-Romero, Lubbertus C. F. Mulder, Thomas Kehrer, Soner Yildiz, Angela Choi, Stephen T. Yeung, Ignacio Mena, Virginia Gillespie, Jana De Vrieze, Sadaf Aslam, Daniel Stadlbauer, David A. Meekins, Chester D. McDowell, Velmurugan Balaraman, Michael J. Corley, Juergen A. Richt, Bruno G. De Geest, Lisa Miorin, PVI study group, Florian Krammer, Luis Martinez-Sobrido, Viviana Simon, Adolfo García-Sastre, Michael Schotsaert
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-022-30763-0

Internet

https://doi.org/10.1038/s41467-022-30763-0