Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera
Here, Rathnasinghe et al. characterize the pathogenesis of a mouse-adapted SARS-CoV-2 in infected obese and aged mice, and identify mutations that are present in SARS-CoV-2 variants of concern, associated with higher transmissibility.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30763-0 |
| _version_ | 1811324416818151424 |
|---|---|
| author | Raveen Rathnasinghe Sonia Jangra Chengjin Ye Anastasija Cupic Gagandeep Singh Carles Martínez-Romero Lubbertus C. F. Mulder Thomas Kehrer Soner Yildiz Angela Choi Stephen T. Yeung Ignacio Mena Virginia Gillespie Jana De Vrieze Sadaf Aslam Daniel Stadlbauer David A. Meekins Chester D. McDowell Velmurugan Balaraman Michael J. Corley Juergen A. Richt Bruno G. De Geest Lisa Miorin PVI study group Florian Krammer Luis Martinez-Sobrido Viviana Simon Adolfo García-Sastre Michael Schotsaert |
| author_facet | Raveen Rathnasinghe Sonia Jangra Chengjin Ye Anastasija Cupic Gagandeep Singh Carles Martínez-Romero Lubbertus C. F. Mulder Thomas Kehrer Soner Yildiz Angela Choi Stephen T. Yeung Ignacio Mena Virginia Gillespie Jana De Vrieze Sadaf Aslam Daniel Stadlbauer David A. Meekins Chester D. McDowell Velmurugan Balaraman Michael J. Corley Juergen A. Richt Bruno G. De Geest Lisa Miorin PVI study group Florian Krammer Luis Martinez-Sobrido Viviana Simon Adolfo García-Sastre Michael Schotsaert |
| author_sort | Raveen Rathnasinghe |
| collection | DOAJ |
| description | Here, Rathnasinghe et al. characterize the pathogenesis of a mouse-adapted SARS-CoV-2 in infected obese and aged mice, and identify mutations that are present in SARS-CoV-2 variants of concern, associated with higher transmissibility. |
| first_indexed | 2024-04-13T14:13:55Z |
| format | Article |
| id | doaj.art-12c6e893f2b043239df7246c95215cf6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T14:13:55Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-12c6e893f2b043239df7246c95215cf62022-12-22T02:43:42ZengNature PortfolioNature Communications2041-17232022-07-0113111410.1038/s41467-022-30763-0Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune seraRaveen Rathnasinghe0Sonia Jangra1Chengjin Ye2Anastasija Cupic3Gagandeep Singh4Carles Martínez-Romero5Lubbertus C. F. Mulder6Thomas Kehrer7Soner Yildiz8Angela Choi9Stephen T. Yeung10Ignacio Mena11Virginia Gillespie12Jana De Vrieze13Sadaf Aslam14Daniel Stadlbauer15David A. Meekins16Chester D. McDowell17Velmurugan Balaraman18Michael J. Corley19Juergen A. Richt20Bruno G. De Geest21Lisa Miorin22PVI study groupFlorian Krammer23Luis Martinez-Sobrido24Viviana Simon25Adolfo García-Sastre26Michael Schotsaert27Department of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkTexas Biomedical Research InstituteDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkCenter for Comparative Medicine and Surgery, Icahn School of Medicine at Mount Sinai New YorkDepartment of Pharmaceutics, Ghent UniversityDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State UniversityDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State UniversityDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State UniversityDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New YorkDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State UniversityDepartment of Pharmaceutics, Ghent UniversityDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkTexas Biomedical Research InstituteDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai New YorkHere, Rathnasinghe et al. characterize the pathogenesis of a mouse-adapted SARS-CoV-2 in infected obese and aged mice, and identify mutations that are present in SARS-CoV-2 variants of concern, associated with higher transmissibility.https://doi.org/10.1038/s41467-022-30763-0 |
| spellingShingle | Raveen Rathnasinghe Sonia Jangra Chengjin Ye Anastasija Cupic Gagandeep Singh Carles Martínez-Romero Lubbertus C. F. Mulder Thomas Kehrer Soner Yildiz Angela Choi Stephen T. Yeung Ignacio Mena Virginia Gillespie Jana De Vrieze Sadaf Aslam Daniel Stadlbauer David A. Meekins Chester D. McDowell Velmurugan Balaraman Michael J. Corley Juergen A. Richt Bruno G. De Geest Lisa Miorin PVI study group Florian Krammer Luis Martinez-Sobrido Viviana Simon Adolfo García-Sastre Michael Schotsaert Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera Nature Communications |
| title | Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera |
| title_full | Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera |
| title_fullStr | Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera |
| title_full_unstemmed | Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera |
| title_short | Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera |
| title_sort | characterization of sars cov 2 spike mutations important for infection of mice and escape from human immune sera |
| url | https://doi.org/10.1038/s41467-022-30763-0 |
| work_keys_str_mv | AT raveenrathnasinghe characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT soniajangra characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT chengjinye characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT anastasijacupic characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT gagandeepsingh characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT carlesmartinezromero characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT lubbertuscfmulder characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT thomaskehrer characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT soneryildiz characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT angelachoi characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT stephentyeung characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT ignaciomena characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT virginiagillespie characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT janadevrieze characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT sadafaslam characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT danielstadlbauer characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT davidameekins characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT chesterdmcdowell characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT velmuruganbalaraman characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT michaeljcorley characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT juergenaricht characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT brunogdegeest characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT lisamiorin characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT pvistudygroup characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT floriankrammer characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT luismartinezsobrido characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT vivianasimon characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT adolfogarciasastre characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera AT michaelschotsaert characterizationofsarscov2spikemutationsimportantforinfectionofmiceandescapefromhumanimmunesera |