The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant role for ABCG2 in urate excretion in both the kidne...

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Bibliographic Details
Main Authors: Kazi Mirajul Hoque, Eryn E. Dixon, Raychel M. Lewis, Jordyn Allan, Gregory D. Gamble, Amanda J. Phipps-Green, Victoria L. Halperin Kuhns, Anne M. Horne, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth, Owen M. Woodward
Format: Article
Language:English
Published: Nature Portfolio 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16525-w

Internet

https://doi.org/10.1038/s41467-020-16525-w

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