Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model

Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model

Abstract Background Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with a mutation in one copy of the neurofibromin gene (NF1 +/− ). Even though approximately 40–60% of children with NF1 meet the criteria for attention deficit hyperactivity disorder (ADHD), very few preclinical stu...

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Bibliographic Details
Main Authors: J. L. Lukkes, H. P. Drozd, S. D. Fitz, A. I. Molosh, D. W. Clapp, A. Shekhar
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Impulsivity
ADHD
Guanfacine
Mouse
Neurofibromatosis type 1
Delay discounting
Online Access:https://doi.org/10.1186/s11689-019-9304-y

Internet

https://doi.org/10.1186/s11689-019-9304-y

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