Suppression of Bcl3 Disrupts Viability of Breast Cancer Cells through Both p53-Dependent and p53-Independent Mechanisms via Loss of NF-κB Signalling

Suppression of Bcl3 Disrupts Viability of Breast Cancer Cells through Both p53-Dependent and p53-Independent Mechanisms via Loss of NF-κB Signalling

The NF-κB co-factor Bcl3 is a proto-oncogene that promotes breast cancer proliferation, metastasis and therapeutic resistance, yet its role in breast cancer cell survival is unclear. Here, we sought to determine the effect of Bcl3 suppression alone on breast cancer cell viability, with a view to inf...

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Bibliographic Details
Main Authors: Daniel J. Turnham, Hannah Smith, Richard W. E. Clarkson
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Biomedicines
Subjects:
Bcl3
senescence
NF-κB
breast cancer
p53
SASP
Online Access:https://www.mdpi.com/2227-9059/12/1/143

Internet

https://www.mdpi.com/2227-9059/12/1/143

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