Polymeric nanoparticles developed by vitamin E-modified aliphatic polycarbonate polymer to promote oral absorption of oleanolic acid

Polymeric nanoparticles developed by vitamin E-modified aliphatic polycarbonate polymer to promote oral absorption of oleanolic acid

Oleanolic acid (OA) exhibited good pharmacological activities in the clinical treatment of hypoglycemia, immune regulation, acute jaundice and chronic toxic hepatitis. However, the oral delivery of OA is greatly limited by its inferior water solubility and poor intestinal mucosa permeability. Herein...

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Bibliographic Details
Main Authors: Wenjuan Zhang, Chufan Liang, Hao Liu, Zhenbao Li, Rui Chen, Mei Zhou, Dan Li, Qing Ye, Cong Luo, Jin Sun
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Oleanolic acid
Polymeric nanoparticles
mPEG-PCC-VE
Oral delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087617304695

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http://www.sciencedirect.com/science/article/pii/S1818087617304695

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