Mechanisms of Glioma Formation: Iterative Perivascular Glioma Growth and Invasion Leads to Tumor Progression, VEGF-Independent Vascularization, and Resistance to Antiangiogenic Therapy

Mechanisms of Glioma Formation: Iterative Perivascular Glioma Growth and Invasion Leads to Tumor Progression, VEGF-Independent Vascularization, and Resistance to Antiangiogenic Therapy

As glioma cells infiltrate the brain they become associated with various microanatomic brain structures such as blood vessels, white matter tracts, and brain parenchyma. How these distinct invasion patterns coordinate tumor growth and influence clinical outcomes remain poorly understood. We have inv...

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Bibliographic Details
Main Authors: Gregory J. Baker, Viveka Nand Yadav, Sebastien Motsch, Carl Koschmann, Anda-Alexandra Calinescu, Yohei Mineharu, Sandra Ines Camelo-Piragua, Daniel Orringer, Serguei Bannykh, Wesley S. Nichols, Ana C. deCarvalho, Tom Mikkelsen, Maria G. Castro, Pedro R. Lowenstein
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558614000773

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http://www.sciencedirect.com/science/article/pii/S1476558614000773

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