The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models.

Three p160 family members, p/CIP, SRC1, and TIF2, have been identified as transcriptional coactivators for nuclear hormone receptors and other transcription factors in vitro. In a previous study, we reported initial characterization of the obesity-resistant phenotypes of p/CIP and SRC-1 double knock...

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Bibliographic Details
Main Authors: Zhiyong Wang, O Jameel Shah, Tony Hunter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3409189?pdf=render