LRRC6 regulates biogenesis of motile cilia by aiding FOXJ1 translocation into the nucleus

LRRC6 regulates biogenesis of motile cilia by aiding FOXJ1 translocation into the nucleus

Abstract Background LRRC6 is an assembly factor for dynein arms in the cytoplasm of motile ciliated cells, and when mutated, dynein arm components remained in the cytoplasm. Here, we demonstrate the role of LRRC6 in the active nuclear translocation of FOXJ1, a master regulator for cilia-associated g...

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Bibliographic Details
Main Authors: Dong Yun Kim, Yu Jin Sub, Hye-Youn Kim, Kyeong Jee Cho, Won Il Choi, Yo Jun Choi, Min Goo Lee, Friedhelm Hildebrandt, Heon Yung Gee
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cell Communication and Signaling
Subjects:
Motile cilia
Primary ciliary dyskinesia
LRRC6
FOXJ1
Nuclear translocation
Online Access:https://doi.org/10.1186/s12964-023-01135-y

Internet

https://doi.org/10.1186/s12964-023-01135-y

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