Chromatin complex dependencies reveal targeting opportunities in leukemia

Chromatin complex dependencies reveal targeting opportunities in leukemia

Epigenetic regulators are potential therapeutic drug targets in leukemia. Here, the authors perform combinatorial CRISPR knockouts to test gene-gene pairings in leukemia cells to discover compensatory non-lethal or synergistic lethal combinations with therapeutic potential.

Bibliographic Details
Main Authors: Fadi J. Najm, Peter DeWeirdt, Molly M. Moore, Samantha M. Bevill, Chadi A. El Farran, Kevin A. Macias, Mudra Hegde, Amanda L. Waterbury, Brian B. Liau, Peter van Galen, John G. Doench, Bradley E. Bernstein
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36150-7

Internet

https://doi.org/10.1038/s41467-023-36150-7

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