Chromatin complex dependencies reveal targeting opportunities in leukemia

Chromatin complex dependencies reveal targeting opportunities in leukemia

Epigenetic regulators are potential therapeutic drug targets in leukemia. Here, the authors perform combinatorial CRISPR knockouts to test gene-gene pairings in leukemia cells to discover compensatory non-lethal or synergistic lethal combinations with therapeutic potential.

Dades bibliogràfiques
Autors principals: Fadi J. Najm, Peter DeWeirdt, Molly M. Moore, Samantha M. Bevill, Chadi A. El Farran, Kevin A. Macias, Mudra Hegde, Amanda L. Waterbury, Brian B. Liau, Peter van Galen, John G. Doench, Bradley E. Bernstein
Format: Article
Idioma:English
Publicat: Nature Portfolio 2023-01-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-023-36150-7

Internet

https://doi.org/10.1038/s41467-023-36150-7

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