Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates

Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates

Tumor metastasis into the central nervous system (CNS) and lymph nodes (LNs) is a major obstacle for effective therapies. Therapeutic monoclonal antibodies (mAb) have revolutionized tumor treatment; however, their efficacy for treating metastatic tumors-particularly, CNS and LN metastases-is poor du...

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Bibliographic Details
Main Authors: Meng Qin, Lan Wang, Di Wu, Christopher K. Williams, Duo Xu, Emiko Kranz, Qi Guo, Jiaoqiong Guan, Harry V. Vinters, YooJin Lee, Yiming Xie, Yun Luo, Guibo Sun, Xiaobo Sun, Zhanlong He, Yunfeng Lu, Masakazu Kamata, Jing Wen, Irvin S. Y. Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
monoclonal antibody
central nervous system delivery
LNs delivery
non-human primate
nanocapsules
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03132/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03132/full

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