The relationship between glucose and the liver-alpha cell axis – A systematic review
Until recently, glucagon was considered a mere antagonist to insulin, protecting the body from hypoglycemia. This notion changed with the discovery of the liver-alpha cell axis (LACA) as a feedback loop. The LACA describes how glucagon secretion and pancreatic alpha cell proliferation are stimulated...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1061682/full |
| _version_ | 1797960665104646144 |
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| author | Thomas Pixner Thomas Pixner Nathalie Stummer Nathalie Stummer Anna Maria Schneider Anna Maria Schneider Andreas Lukas Andreas Lukas Karin Gramlinger Valérie Julian David Thivel Katharina Mörwald Katharina Mörwald Harald Mangge Christopher Dalus Christopher Dalus Elmar Aigner Elmar Aigner Dieter Furthner Dieter Furthner Daniel Weghuber Daniel Weghuber Katharina Maruszczak Katharina Maruszczak |
| author_facet | Thomas Pixner Thomas Pixner Nathalie Stummer Nathalie Stummer Anna Maria Schneider Anna Maria Schneider Andreas Lukas Andreas Lukas Karin Gramlinger Valérie Julian David Thivel Katharina Mörwald Katharina Mörwald Harald Mangge Christopher Dalus Christopher Dalus Elmar Aigner Elmar Aigner Dieter Furthner Dieter Furthner Daniel Weghuber Daniel Weghuber Katharina Maruszczak Katharina Maruszczak |
| author_sort | Thomas Pixner |
| collection | DOAJ |
| description | Until recently, glucagon was considered a mere antagonist to insulin, protecting the body from hypoglycemia. This notion changed with the discovery of the liver-alpha cell axis (LACA) as a feedback loop. The LACA describes how glucagon secretion and pancreatic alpha cell proliferation are stimulated by circulating amino acids. Glucagon in turn leads to an upregulation of amino acid metabolism and ureagenesis in the liver. Several increasingly common diseases (e.g., non-alcoholic fatty liver disease, type 2 diabetes, obesity) disrupt this feedback loop. It is important for clinicians and researchers alike to understand the liver-alpha cell axis and the metabolic sequelae of these diseases. While most of previous studies have focused on fasting concentrations of glucagon and amino acids, there is limited knowledge of their dynamics after glucose administration. The authors of this systematic review applied PRISMA guidelines and conducted PubMed searches to provide results of 8078 articles (screened and if relevant, studied in full). This systematic review aims to provide better insight into the LACA and its mediators (amino acids and glucagon), focusing on the relationship between glucose and the LACA in adult and pediatric subjects. |
| first_indexed | 2024-04-11T00:48:37Z |
| format | Article |
| id | doaj.art-12d8f4421a15448e8937a1bdad93a6d0 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T00:48:37Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-12d8f4421a15448e8937a1bdad93a6d02023-01-05T10:10:57ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011310.3389/fendo.2022.10616821061682The relationship between glucose and the liver-alpha cell axis – A systematic reviewThomas Pixner0Thomas Pixner1Nathalie Stummer2Nathalie Stummer3Anna Maria Schneider4Anna Maria Schneider5Andreas Lukas6Andreas Lukas7Karin Gramlinger8Valérie Julian9David Thivel10Katharina Mörwald11Katharina Mörwald12Harald Mangge13Christopher Dalus14Christopher Dalus15Elmar Aigner16Elmar Aigner17Dieter Furthner18Dieter Furthner19Daniel Weghuber20Daniel Weghuber21Katharina Maruszczak22Katharina Maruszczak23Department of Pediatric and Adolescent Medicine, Salzkammergutklinikum Voecklabruck, Voecklabruck, AustriaObesity Research Unit, Paracelsus Medical University, Salzburg, AustriaObesity Research Unit, Paracelsus Medical University, Salzburg, AustriaDepartment of Pediatrics, Paracelsus Medical University, Salzburg, AustriaObesity Research Unit, Paracelsus Medical University, Salzburg, AustriaDepartment of Pediatrics, Paracelsus Medical University, Salzburg, AustriaDepartment of Pediatric and Adolescent Medicine, Salzkammergutklinikum Voecklabruck, Voecklabruck, AustriaObesity Research Unit, Paracelsus Medical University, Salzburg, AustriaDepartment of Pediatric and Adolescent Medicine, Salzkammergutklinikum Voecklabruck, Voecklabruck, AustriaDepartment of Sport Medicine and Functional Explorations, Diet and Musculoskeletal Health Team, Human Nutrition Research Center (CRNH), INRA, University Hospital of Clermont-Ferrand, University of Clermont Auvergne, Clermont-Ferrand, FranceLaboratory of Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), University of Clermont Auvergne, Clermont-Ferrand, FranceObesity Research Unit, Paracelsus Medical University, Salzburg, AustriaDepartment of Pediatrics, Paracelsus Medical University, Salzburg, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, AustriaObesity Research Unit, Paracelsus Medical University, Salzburg, AustriaDepartment of Pediatrics, Paracelsus Medical University, Salzburg, AustriaObesity Research Unit, Paracelsus Medical University, Salzburg, AustriaFirst Department of Medicine, Paracelsus Medical University, Salzburg, AustriaDepartment of Pediatric and Adolescent Medicine, Salzkammergutklinikum Voecklabruck, Voecklabruck, AustriaObesity Research Unit, Paracelsus Medical University, Salzburg, AustriaObesity Research Unit, Paracelsus Medical University, Salzburg, AustriaDepartment of Pediatrics, Paracelsus Medical University, Salzburg, AustriaObesity Research Unit, Paracelsus Medical University, Salzburg, AustriaDepartment of Pediatrics, Paracelsus Medical University, Salzburg, AustriaUntil recently, glucagon was considered a mere antagonist to insulin, protecting the body from hypoglycemia. This notion changed with the discovery of the liver-alpha cell axis (LACA) as a feedback loop. The LACA describes how glucagon secretion and pancreatic alpha cell proliferation are stimulated by circulating amino acids. Glucagon in turn leads to an upregulation of amino acid metabolism and ureagenesis in the liver. Several increasingly common diseases (e.g., non-alcoholic fatty liver disease, type 2 diabetes, obesity) disrupt this feedback loop. It is important for clinicians and researchers alike to understand the liver-alpha cell axis and the metabolic sequelae of these diseases. While most of previous studies have focused on fasting concentrations of glucagon and amino acids, there is limited knowledge of their dynamics after glucose administration. The authors of this systematic review applied PRISMA guidelines and conducted PubMed searches to provide results of 8078 articles (screened and if relevant, studied in full). This systematic review aims to provide better insight into the LACA and its mediators (amino acids and glucagon), focusing on the relationship between glucose and the LACA in adult and pediatric subjects.https://www.frontiersin.org/articles/10.3389/fendo.2022.1061682/fullliver-alpha cell axisglucagonglucoseliverOGTTpediatric |
| spellingShingle | Thomas Pixner Thomas Pixner Nathalie Stummer Nathalie Stummer Anna Maria Schneider Anna Maria Schneider Andreas Lukas Andreas Lukas Karin Gramlinger Valérie Julian David Thivel Katharina Mörwald Katharina Mörwald Harald Mangge Christopher Dalus Christopher Dalus Elmar Aigner Elmar Aigner Dieter Furthner Dieter Furthner Daniel Weghuber Daniel Weghuber Katharina Maruszczak Katharina Maruszczak The relationship between glucose and the liver-alpha cell axis – A systematic review Frontiers in Endocrinology liver-alpha cell axis glucagon glucose liver OGTT pediatric |
| title | The relationship between glucose and the liver-alpha cell axis – A systematic review |
| title_full | The relationship between glucose and the liver-alpha cell axis – A systematic review |
| title_fullStr | The relationship between glucose and the liver-alpha cell axis – A systematic review |
| title_full_unstemmed | The relationship between glucose and the liver-alpha cell axis – A systematic review |
| title_short | The relationship between glucose and the liver-alpha cell axis – A systematic review |
| title_sort | relationship between glucose and the liver alpha cell axis a systematic review |
| topic | liver-alpha cell axis glucagon glucose liver OGTT pediatric |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1061682/full |
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