Bi-allelic amplification of ATM gene in blastoid variant of mantle cell lymphoma: a novel mechanism of inactivation due to chromoanagenesis?

Bi-allelic amplification of ATM gene in blastoid variant of mantle cell lymphoma: a novel mechanism of inactivation due to chromoanagenesis?

Abstract Background Mantle cell lymphoma (MCL) is derived from naïve CD5+ B-cells with the cytogenetic hallmark translocation 11;14. The presence of additional abnormalities is associated with blastoid variants in MCL (BMCL) and confers a poor prognosis. Many of these tumors also show deletion or lo...

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Bibliographic Details
Main Authors: Veronica Ortega, Christina Mendiola, Juana Rodriguez, William Ehman, You-Wen Qian, Gopalrao Velagaleti
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Molecular Cytogenetics
Subjects:
Mantle cell lymphoma (MCL)
Blastoid mantle cell lymphoma (BMCL)
Loss of heterozygosity (LOH)
Single nucleotide polymorphism (SNP)
Mutant allele specific imbalance (MASI)
Copy number gain (CNG)
Online Access:https://doi.org/10.1186/s13039-020-00526-x

Internet

https://doi.org/10.1186/s13039-020-00526-x

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