Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle

Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle

The hetero-octameric protein complex, Augmin, recruits γ-Tubulin ring complex (γ-TuRC) to pre-existing microtubules (MTs) to generate branched MTs during mitosis, facilitating robust spindle assembly. However, despite a recent partial reconstitution of the human Augmin complex in vitro, the molecula...

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Bibliographic Details
Main Authors: Jack W. C. Chen, Zhuo A. Chen, Kacper B. Rogala, Jeremy Metz, Charlotte M. Deane, Juri Rappsilber, James G. Wakefield
Format: Article
Language:English
Published: The Company of Biologists 2017-05-01
Series:Biology Open
Subjects:
γ-TuRC
Augmin
Drosophila
Microtubule
Mitosis
Spindle
Online Access:http://bio.biologists.org/content/6/5/654

Internet

http://bio.biologists.org/content/6/5/654

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