CRISPR screening identifies T cell-intrinsic regulators of CD3-bispecific antibody responses

CRISPR screening identifies T cell-intrinsic regulators of CD3-bispecific antibody responses

CD3-engaging bispecific antibodies (BsAbs) enable the formation of an immune synapse between T cells and tumor cells, resulting in robust target cell killing not dependent on a preexisting tumor specific T cell receptor. While recent studies have shed light on tumor cell-specific factors that modula...

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Bibliographic Details
Main Authors: Ryan D. Molony, Theresa Funk, Gina Trabucco, Erik Corcoran, David Ruddy, Malini Varadarajan, GiNell Elliot, Michelle Piquet, Joni Lam, Matthew J. Meyer, Hui Qin Wang, Sema Kurtulus, Haihui Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
Bispecific antibodies
T cells
immunotherapy
CRISPR screening
mTOR
EP300
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.909979/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.909979/full

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