Attenuating RNA Viruses with Expanded Genetic Codes to Evoke Adjustable Immune Response in PylRS-<inline-formula><math display="inline"><semantics><msubsup><mrow><mi mathvariant="bold">tRNA</mi></mrow><mrow><mi mathvariant="bold">CUA</mi></mrow><mrow><mi mathvariant="bold">Pyl</mi></mrow></msubsup></semantics></math></inline-formula> Transgenic Mice

Ribonucleic acid (RNA) viruses pose heavy burdens on public-health systems. Synthetic biology holds great potential for artificially controlling their replication, a strategy that could be used to attenuate infectious viruses but is still in the exploratory stage. Herein, we used the genetic-code ex...

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Bibliographic Details
Main Authors: Zhetao Zheng, Xuesheng Wu, Yu Wang, Xu Yang, Hongmin Chen, Yuxuan Shen, Yuelin Yang, Qing Xia
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/11/10/1606