Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice

Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice

Abstract Background Current influenza vaccines deliver satisfactory results in young people but are less effective in the elderly. Development of vaccines for an ever-increasing aging population has been an arduous challenge due to immunosenescence that impairs the immune response in the aged, both...

Full description

Bibliographic Details
Main Authors: Bo Ryoung Park, Ramireddy Bommireddy, David Hyunjung Chung, Ki-Hye Kim, Jeeva Subbiah, Yu-Jin Jung, Noopur Bhatnagar, Christopher D. Pack, Sampath Ramachandiran, Shaker J.C. Reddy, Periasamy Selvaraj, Sang-Moo Kang
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Immunity & Ageing
Subjects:
Influenza
Virus-like particles (HA-VLPs)
Hemagglutinin (HA)
Cross protection
Cytokine adjuvants
GPI-IL-12
Online Access:https://doi.org/10.1186/s12979-023-00344-w

Internet

https://doi.org/10.1186/s12979-023-00344-w

Similar Items