IgM Antibodies Can Access Cryptic Antigens Denied to IgG: Hypothesis on Novel Binding Mechanism

IgM Antibodies Can Access Cryptic Antigens Denied to IgG: Hypothesis on Novel Binding Mechanism

Antibodies are well-known protein mediators of immunity. IgM is the primordial member and the neglected sibling of the later-evolved and more proficient IgG in regard to their therapeutic and diagnostic use. Serendipitously, however, we found a paradox: While murine IgM antibodies specific for guano...

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Bibliographic Details
Main Authors: Eric Chun Yiu Law, Danny Tze Ming Leung, Frankie Chi Hang Tam, Kitty Kit Ting Cheung, Naomi Hua Yin Cheng, Pak Leong Lim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
IgM
antibody specificity
guanosine triphosphate
lock-and-key
antigen-binding site
steric hindrance
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01820/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01820/full

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