Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Abstract Alzheimer’s Disease (AD) is characterized by the accumulation of extracellular amyloid-β (Aβ) as well as CNS and systemic inflammation. Microglia, the myeloid cells resident in the CNS, use microRNAs to rapidly respond to inflammatory signals. MicroRNAs (miRNAs) modulate inflammatory respon...

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Bibliographic Details
Main Authors: Macarena S. Aloi, Katherine E. Prater, Raymond E. A. Sánchez, Asad Beck, Jasmine L. Pathan, Stephanie Davidson, Angela Wilson, C. Dirk Keene, Horacio de la Iglesia, Suman Jayadev, Gwenn A. Garden
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Mouse models
miR-155
Microglia
Inducible knock-out
Epilepsy
Online Access:https://doi.org/10.1186/s12974-023-02745-6

Internet

https://doi.org/10.1186/s12974-023-02745-6

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