Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – Histone Deacetylase 2 Interaction in Human Cells

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – Histone Deacetylase 2 Interaction in Human Cells

We recently identified lamin A/C as a docking molecule for human histone deacetylase 2 (HDAC2) and showed involvement of HDAC2-lamin A/C complexes in the DNA damage response. We further showed that lamin A/C-HDAC2 interaction is altered in Hutchinson-Gilford Progeria syndrome and other progeroid lam...

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Bibliographic Details
Main Authors: Elisabetta Mattioli, Davide Andrenacci, Antonello Mai, Sergio Valente, Joke Robijns, Winnok H. De Vos, Cristina Capanni, Giovanna Lattanzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
prelamin A
LMNA gene
HDAC2
statins
HDAC inhibitors
trichostatin A (TSA)
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00006/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00006/full

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