Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E

Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E

Abstract Background Pancreatic cancer is one of the most malignant cancers. The overall 5-year survival rate of its patients is 8%, the lowest among major cancer types. It is very urgent to study the development mechanisms of this cancer and provide potential targets for therapeutics design. Glucose...

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Bibliographic Details
Main Authors: Xuhui Ma, Boya Li, Jie Liu, Yan Fu, Yongzhang Luo
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PHGDH
eIF4A1
eIF4E
Translation initiation
Pancreatic cancer development
Online Access:http://link.springer.com/article/10.1186/s13046-019-1053-y

Internet

http://link.springer.com/article/10.1186/s13046-019-1053-y

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