Spatial Rule-Based Modeling: A Method and Its Application to the Human Mitotic Kinetochore

Spatial Rule-Based Modeling: A Method and Its Application to the Human Mitotic Kinetochore

A common problem in the analysis of biological systems is the combinatorial explosion that emerges from the complexity of multi-protein assemblies. Conventional formalisms, like differential equations, Boolean networks and Bayesian networks, are unsuitable for dealing with the combinatorial explosio...

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Bibliographic Details
Main Authors: Jan Huwald, Peter Dittrich, Matthew Egbert, Gerd Gruenert, Richard Henze, Bashar Ibrahim
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Cells
Subjects:
rule-based
modeling
simulation
3D space
SRSim software
kinetochore structure
spindle assembly checkpoint
mitosis
structural analysis
Online Access:http://www.mdpi.com/2073-4409/2/3/506

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http://www.mdpi.com/2073-4409/2/3/506

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