Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the integrated stress response phosphorylate eIF2 serine-51, inhibiting nucleotide exchange by eIF2B. ISRIB, a potent drug-like small molecule, renders cells insensitive to eIF2α pho...

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Bibliographic Details
Main Authors: Carmela Sidrauski, Jordan C Tsai, Martin Kampmann, Brian R Hearn, Punitha Vedantham, Priyadarshini Jaishankar, Masaaki Sokabe, Aaron S Mendez, Billy W Newton, Edward L Tang, Erik Verschueren, Jeffrey R Johnson, Nevan J Krogan, Christopher S Fraser, Jonathan S Weissman, Adam R Renslo, Peter Walter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-04-01
Series:eLife
Subjects:
eIF2B
eIF2
integrated stress response
ISRIB
unfolded protein response
protein synthesis
Online Access:https://elifesciences.org/articles/07314

Internet

https://elifesciences.org/articles/07314

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