Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response
The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the integrated stress response phosphorylate eIF2 serine-51, inhibiting nucleotide exchange by eIF2B. ISRIB, a potent drug-like small molecule, renders cells insensitive to eIF2α pho...
Main Authors: | , , , , , , , , , , , , , , , , |
---|---|
格式: | 文件 |
语言: | English |
出版: |
eLife Sciences Publications Ltd
2015-04-01
|
丛编: | eLife |
主题: | |
在线阅读: | https://elifesciences.org/articles/07314 |