Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response
The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the integrated stress response phosphorylate eIF2 serine-51, inhibiting nucleotide exchange by eIF2B. ISRIB, a potent drug-like small molecule, renders cells insensitive to eIF2α pho...
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Fformat: | Erthygl |
Iaith: | English |
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eLife Sciences Publications Ltd
2015-04-01
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Cyfres: | eLife |
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Mynediad Ar-lein: | https://elifesciences.org/articles/07314 |